Routine blood tests during pregnancy for predicting future increases in risk of cardiovascular morbidity (2024)

Yuval Bar-Asher, S., Shefer, A., Shoham-Vardi, I., Sergienko, R., Wolak, A., Sheiner, E., & Wolak, T. (2018). Routine blood tests during pregnancy for predicting future increases in risk of cardiovascular morbidity. International Journal of Gynecology and Obstetrics, 143(2), 178-183. https://doi.org/10.1002/ijgo.12592

Yuval Bar-Asher, Shira ; Shefer, Alexander ; Shoham-Vardi, Ilana et al. / Routine blood tests during pregnancy for predicting future increases in risk of cardiovascular morbidity. In: International Journal of Gynecology and Obstetrics. 2018 ; Vol. 143, No. 2. pp. 178-183.

@article{19500bad4f264b4fbed4a39d2e335ebb,

title = "Routine blood tests during pregnancy for predicting future increases in risk of cardiovascular morbidity",

abstract = "Objective: To examine the association between routine blood tests during pregnancy and future risk of cardiovascular morbidity. Methods: The present case–control study was conducted among women who delivered at a teaching hospital in Israel between January 1, 2000, and December 31, 2012. The cohort comprised women who were subsequently hospitalized owing to cardiovascular morbidity (case group) and age-matched non-hospitalized women (control group). Blood levels of creatinine, glucose, potassium, urea, and uric acid were measured during pregnancy. Only women with at least one test result available for all five measurements were included. The relationship between upper quartile blood test values and cardiovascular hospitalization was assessed. Results: The study included 4115 women (212 in the case group and 3903 in the control group). Three measures were associated with a future risk of cardiovascular morbidity requiring hospitalization: creatinine (hazard ratio [HR] 1.86, 95% confidence interval [CI] 1.37–2.53; P<0.001); potassium (HR 1.48, 95% CI 1.09–2.01; P=0.013), and urea (HR 1.60, 95% CI 1.17–2.19; P=0.003). The number of blood test results in the upper quartile also increased such risk. The HRs for two tests and at least three tests were 1.65 (95% CI 1.06–2.56; P=0.026) and 3.32 (95% CI 2.19–5.04; P<0.001), respectively. Conclusions: Future cardiovascular morbidity was predicted by routine blood tests during pregnancy.",

keywords = "Cardiovascular disease, Creatinine, Potassium, Pregnancy, Urea, Uric acid",

author = "{Yuval Bar-Asher}, Shira and Alexander Shefer and Ilana Shoham-Vardi and Ruslan Sergienko and Arik Wolak and Eyal Sheiner and Talya Wolak",

note = "Publisher Copyright: {\textcopyright} 2018 International Federation of Gynecology and Obstetrics",

year = "2018",

month = nov,

day = "1",

doi = "10.1002/ijgo.12592",

language = "English",

volume = "143",

pages = "178--183",

journal = "International Journal of Gynecology and Obstetrics",

issn = "0020-7292",

publisher = "John Wiley and Sons Ltd",

number = "2",

}

Yuval Bar-Asher, S, Shefer, A, Shoham-Vardi, I, Sergienko, R, Wolak, A, Sheiner, E & Wolak, T 2018, 'Routine blood tests during pregnancy for predicting future increases in risk of cardiovascular morbidity', International Journal of Gynecology and Obstetrics, vol. 143, no. 2, pp. 178-183. https://doi.org/10.1002/ijgo.12592

Routine blood tests during pregnancy for predicting future increases in risk of cardiovascular morbidity. / Yuval Bar-Asher, Shira; Shefer, Alexander; Shoham-Vardi, Ilana et al.
In: International Journal of Gynecology and Obstetrics, Vol. 143, No. 2, 01.11.2018, p. 178-183.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Routine blood tests during pregnancy for predicting future increases in risk of cardiovascular morbidity

AU - Yuval Bar-Asher, Shira

AU - Shefer, Alexander

AU - Shoham-Vardi, Ilana

AU - Sergienko, Ruslan

AU - Wolak, Arik

AU - Sheiner, Eyal

AU - Wolak, Talya

N1 - Publisher Copyright:© 2018 International Federation of Gynecology and Obstetrics

PY - 2018/11/1

Y1 - 2018/11/1

N2 - Objective: To examine the association between routine blood tests during pregnancy and future risk of cardiovascular morbidity. Methods: The present case–control study was conducted among women who delivered at a teaching hospital in Israel between January 1, 2000, and December 31, 2012. The cohort comprised women who were subsequently hospitalized owing to cardiovascular morbidity (case group) and age-matched non-hospitalized women (control group). Blood levels of creatinine, glucose, potassium, urea, and uric acid were measured during pregnancy. Only women with at least one test result available for all five measurements were included. The relationship between upper quartile blood test values and cardiovascular hospitalization was assessed. Results: The study included 4115 women (212 in the case group and 3903 in the control group). Three measures were associated with a future risk of cardiovascular morbidity requiring hospitalization: creatinine (hazard ratio [HR] 1.86, 95% confidence interval [CI] 1.37–2.53; P<0.001); potassium (HR 1.48, 95% CI 1.09–2.01; P=0.013), and urea (HR 1.60, 95% CI 1.17–2.19; P=0.003). The number of blood test results in the upper quartile also increased such risk. The HRs for two tests and at least three tests were 1.65 (95% CI 1.06–2.56; P=0.026) and 3.32 (95% CI 2.19–5.04; P<0.001), respectively. Conclusions: Future cardiovascular morbidity was predicted by routine blood tests during pregnancy.

AB - Objective: To examine the association between routine blood tests during pregnancy and future risk of cardiovascular morbidity. Methods: The present case–control study was conducted among women who delivered at a teaching hospital in Israel between January 1, 2000, and December 31, 2012. The cohort comprised women who were subsequently hospitalized owing to cardiovascular morbidity (case group) and age-matched non-hospitalized women (control group). Blood levels of creatinine, glucose, potassium, urea, and uric acid were measured during pregnancy. Only women with at least one test result available for all five measurements were included. The relationship between upper quartile blood test values and cardiovascular hospitalization was assessed. Results: The study included 4115 women (212 in the case group and 3903 in the control group). Three measures were associated with a future risk of cardiovascular morbidity requiring hospitalization: creatinine (hazard ratio [HR] 1.86, 95% confidence interval [CI] 1.37–2.53; P<0.001); potassium (HR 1.48, 95% CI 1.09–2.01; P=0.013), and urea (HR 1.60, 95% CI 1.17–2.19; P=0.003). The number of blood test results in the upper quartile also increased such risk. The HRs for two tests and at least three tests were 1.65 (95% CI 1.06–2.56; P=0.026) and 3.32 (95% CI 2.19–5.04; P<0.001), respectively. Conclusions: Future cardiovascular morbidity was predicted by routine blood tests during pregnancy.

KW - Cardiovascular disease

KW - Creatinine

KW - Potassium

KW - Pregnancy

KW - Urea

KW - Uric acid

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U2 - 10.1002/ijgo.12592

DO - 10.1002/ijgo.12592

M3 - Article

C2 - 29981146

AN - SCOPUS:85054183898

SN - 0020-7292

VL - 143

SP - 178

EP - 183

JO - International Journal of Gynecology and Obstetrics

JF - International Journal of Gynecology and Obstetrics

IS - 2

ER -

Yuval Bar-Asher S, Shefer A, Shoham-Vardi I, Sergienko R, Wolak A, Sheiner E et al. Routine blood tests during pregnancy for predicting future increases in risk of cardiovascular morbidity. International Journal of Gynecology and Obstetrics. 2018 Nov 1;143(2):178-183. doi: 10.1002/ijgo.12592