acetaminophen and oxycodone | Cigna (2024)

FAQs

What painkiller can you take with oxycodone? ›

Taking oxycodone with other painkillers

It's safe to take oxycodone with paracetamol, ibuprofen or aspirin (do not give aspirin to children under 16 years of age). Do not take oxycodone with painkillers that contain codeine.

A 2009 study found that the combination of oxycodone and acetaminophen was 1.5 times more potent than hydrocodone with acetaminophen when taken at equal doses.

Standard oxycodone takes 30 to 60 minutes to work, but this wears off after 4 to 6 hours. Slow-release oxycodone can take 1 to 2 days to work fully, but the pain relief will last longer. Are there any long-term side effects? Some people who need long-term pain relief may need to take oxycodone for a long time.

Meaning. This study found that oxycodone did not provide superior pain relief compared with combination acetaminophen and codeine during the first 7 days of treatment despite a 6-fold higher dose of opioid being delivered in the strong opioid group.

Oxycodone and acetaminophen combination is used to relieve pain severe enough to require opioid treatment and when other pain medicines did not work well enough or cannot be tolerated.

Do not drink alcohol, take prescription or nonprescription medications that contain alcohol, or use street drugs during your treatment. If you are taking the oxycodone extended-release tablets, swallow them whole; do not chew, break, divide, crush, or dissolve them.

Fentanyl is much stronger than oxycodone and many other opioids. When fentanyl is taken by mouth or by intravenous (IV) injection, it has a stronger effect than most other opioids.

The strength of both Percocet® and oxycodone depends on the formula. For example, 15 mg oxycodone will be stronger than 325 mg/5mg Percocet®. However, if they contain the same amount of oxycodone, Percocet® is usually stronger because it also contains acetaminophen, which boosts its effects.

Separate from their pain-blocking interaction with receptors in the brain, opioids seem to reshape the nervous system to amplify pain signals, even after the original illness or injury subsides.

Does oxycodone make you sleepy or high? ›

What are the risks associated with oxycodone? Opioids are strong pain medicines and can cause life-threatening breathing problems. Oxycodone can cause side effects that include drowsiness, sleepiness or dizziness in some people. You should avoid driving or operating machinery until you know how it affects you.

This medicine may make you dizzy, drowsy, or lightheaded. Do not drive or do anything else that could be dangerous until you know how this medicine affects you.

Opiates are the strongest pain killers we are able to prescribe and can be very effective at treating acute, severe pain caused by injury, surgery or cancer pain. However the role of opiates in chronic pain (pain lasting a long period of time) is less clear. For most people opiates are NOT effective for chronic pain.

Oxycodone is marketed alone as OxyContin® in 10, 20, 40 and 80 mg extended-release tablets and other immediate-release capsules like 5 mg OxyIR®. It is also marketed in combination products with aspirin such as Percodan® or acetaminophen such as Roxicet®. How is it abused? Oxycodone is abused orally or intravenously.

Ibuprofen and oxycodone combination is used to relieve acute, moderate to severe pain.

Dosages. In combination pill, 5 mg oxycodone and 400 mg ibuprofen every 6 hours as needed.

The World Health Organization (WHO) classes both Dilaudid and oxycodone as “potent opioids.” However, generic hydromorphone has a higher potency than generic oxycodone and typically has a longer duration of action.

Can you take oxycodone with tramadol? Because oxycodone is so much more potent than tramadol, doctors do not usually prescribe them together. Because tramadol is so weak, it would usually not confer an added benefit when used alongside a stronger drug like oxycodone.

Adding cyclobenzaprine or oxycodone/acetaminophen to naproxen for the treatment of acute low back pain does nothing more than increase adverse effects.